ABSTRACT
Buscaremos articular a lógica implicada nas doações de material de engendramento (sêmen, óvulos e embriões), praticadas no campo das novas tecnologias reprodutivas (NTR), com o sistema de trocas de algumas sociedades arcaicas, descrito por Marcel Mauss em seu célebre artigo Ensaio sobre a dádiva (1924/1974). Esta articulação será também trabalhada a partir de três importantes intérpretes deste ensaio - Lévi-Strauss, Maurice Godelier e George Bataille -, de modo a extrair dela algumas consequências e explicitar alguns questionamentos que as NTR colocam para a psicanálise e vice-versa.
Questioning the new forms of human fabrication in the light of Marcel Mauss's concept of gift. In this article, we will articulate the logic involved in donations from engenderment material (semen, eggs and embryos), practiced in the field of new reproductive technologies, with the system of exchanges of some archaic societies described by Marcel Mauss in his celebrated article Essay on the gift (1924/1974). This articulation will also be crafted from three important interpreters of this essay - Lévi-Strauss, Maurice Godelier and George Bataille - in order to extract some consequences and clarify some questions that the NRT address to psychoanalysis and vice versa.
Subject(s)
Humans , Child , Adult , Genes, Switch , Psychoanalysis , ReproductionABSTRACT
Introduction A foreign body (FB) is an object or substance foreign to the location where it is found. FBs in the ear, nose, and throat are a common problem frequently encountered in both children and adults. Objective To analyze FBs in terms of type, site, age, and gender distribution and method of removal. Methods A retrospective study was performed in a tertiary care hospital in the central part of Nepal. The study period was from June 2013 to May 2014. The information was obtained from hospital record books. Results A total of 134 patients had FBs in the ear, nose, or throat; 94 were males and 40 were females. Of the 134 patients, 70 (52.23% ) had FB in the ear, 28 (20.89% ) in the nose, and 36 (26.86% ) in the throat. The FB was animate (living) in 28 (40% ) patients with FB in the ear and 1 (3.5% ) patient with FB in the nose, but the FB was inanimate (nonliving) in any patient with FB in the throat, in 42 (60% ) patients with FB in the ear FB, and in 27 (96.4% ) patients with FB of the nose. The FB was removed with or without local anaesthesia (LA) in 98 (73.13% ) patients, and only 36 patients (26.86% ) required general anaesthesia (GA). The most common age group affected was <10 years. Conclusion FBs in the ear and nose were found more frequently in children, and the throat was the most common site of FB in adults and elderly people. Most of the FBs can be easily removed in emergency room or outpatient department. .
Subject(s)
Animals , Humans , Genes, Tumor Suppressor/physiology , Oncogenes/physiology , Receptors, Notch/physiology , Erythrocytes/physiology , Genes, Switch , Hematologic Neoplasms/drug therapy , Hematologic Neoplasms/metabolism , Hematopoiesis/genetics , Hematopoietic Stem Cells/physiology , Megakaryocytes/physiology , Signal Transduction/physiologyABSTRACT
The aim of this systematic review was to identify and characterize articles in indexed scientific journals with quantitative data surveys on administrative or legal proceedings for access to medicines. The SciELO, LILACS, MEDLINE via PubMed, Embase, and Scopus databases were used. We identified 45 articles, of which 17 were selected. The larger studies, each covering between 2,000 and 2,927 lawsuits, were done in the states of São Paulo, Rio de Janeiro, and Santa Catarina, Brazil. Eleven studies specified the type of legal representation, of which six examined cases with public attorneys and five with private attorneys. Only two studies reported whether the lawsuit was individual or class action, and in both the claims were individual. Since the majority of the medicines requested in the lawsuits were medium to high-cost, the review indicates that lawsuits contributed to the incorporation of these drugs into current pharmaceutical care in Brazil.
El objetivo de esta revisión sistemática fue identificar y caracterizar los artículos disponibles en revistas científicas indexadas en bases de datos electrónicas, que llevaron a cabo un estudio cuantitativo de datos, procedimientos administrativos o judiciales sobre la cuestión del acceso a los medicamentos a través de demandas judiciales. Los estudios fueron localizados en las bases de datos SciELO, LILACS, MEDLINE vía PubMed, Embase, Scopus. Se identificaron 45 artículos, de los cuales se seleccionaron 17. Los estudios que se llevaron a cabo engloban de 2.000 a 2.927 procesos judiciales en São Paulo, Río de Janeiro y Santa Catarina, Brasil. En once estudios se realizaron encuestas a los representantes legales de la acción judicial. En seis estudios predominó la representación pública legal y en cinco abogados privados. Sólo dos estudios examinaron si la acción era individual o colectiva y en los dos hubo prevalencia de acciones individuales. Como la mayoría de los medicamentos estaba involucrada en acciones legales de medio y alto coste, se cree que las demandas han contribuido a la incorporación de fármacos en la política pública actual.
O objetivo desta revisão sistemática foi identificar e caracterizar artigos disponíveis em periódicos científicos indexados em bases eletrônicas, que realizaram levantamento de dados quantitativo, em processos administrativos ou judiciais, sobre a questão do acesso a medicamentos por meio de ações judiciais. Foram usadas as bases de dados SciELO, LILACS, MEDLINE via PubMed, Embase e Scopus. Identificamos 45 artigos, dos quais foram selecionados 17 artigos. Os estudos com faixa de 2.000 a 2.927 processos foram conduzidos em São Paulo, Rio de Janeiro e Santa Catarina, Brasil. Em 11 estudos foram pesquisadas qual a representação jurídica da ação. Em seis estudos predominaram a representação de advogados públicos e em cinco particulares. Somente dois estudos observaram se a ação era coletiva ou individual, sendo que nas duas pesquisas a prevalência era de ações individuais. Como a maioria dos medicamentos envolvidos nas ações é de médio e alto custo, acredita-se que as demandas judiciais tenham contribuído para incorporação de medicamentos nas ações de assistência farmacêutica atuais.
Subject(s)
Bacteriophage lambda/genetics , DNA, Viral/physiology , Genes, Switch , Genomic Instability , Binding Sites , DNA, Viral/chemistry , Gene Expression Regulation, Viral , Lysogeny/genetics , Models, Genetic , Mutation , Nucleic Acid Conformation , Operator Regions, Genetic , Stochastic ProcessesABSTRACT
ATP-dependent chromatin remodeling by the mating type switching/sucrose non-fermenting (SWI/SNF) complex is a basic biological event in the body, which is required for all the key processes involved in DNA metabolism such as gene expression, DNA replication, repair, chromosomal recombination and mitosis. In the past few years, increasing evidence supports a crucial role of this complex in prostate cancer development and progression via multiple ways, such as cell cycle regulation, androgen receptor pathway and DNA methylation. The present paper briefly reviews the recent studies on the association between the SWI/SNF complex and prostate cancer.